Batten disease

Batten disease is a fatal inherited disorder of the nervous system, which typically develops between the ages of two and six. The disease has several different forms that share the same symptoms and causes, but vary in severity and age of onset.

  • 4 children per year are diagnosed in New Zealand.
  • Batten disease affects around 6 in every 100,000 live births.
  • The average life expectancy ranges from 8 years to 20 years.

Children with the disease will often develop normally up to the point where symptoms start to appear. However, the symptoms are devastating and progress quickly, causing blindness, deafness and paralysis in children often before they become teenagers.

As Batten disease is genetic, it may affect more than one person in a family. The rarity of the disease means that it receives relatively low levels of funding around the world compared to other neurological disorders. This makes funding research in New Zealand so much more important.

Signs and symptoms

Batten disease is typically diagnosed when a parent or doctor notices that a child has started to progressively lose vision or develop seizures that were previously not present. Symptoms are often subtle to begin with and vary greatly, but can also include clumsiness and behavioural changes.

As symptoms progress, children will become blind, paralysed and unable to communicate. Life expectancy depends on the age of onset, but very few children with Batten disease survive beyond their late teens.

Causes and treatment

Batten disease is caused by a defective gene that causes fatty substances to build up in the brain, killing off brain cells and cells in other parts of the central nervous system. To inherit the disease, a child must have two parents who are both carriers of the defective gene. A child with two carrier parents has a 25 per cent chance of contracting the disease and a 50 per cent chance of becoming a carrier.

There is no known cure for Batten disease, but research is advancing rapidly at Otago and Lincoln Universities. Researchers at these two South Island universities have for some time bred sheep with Batten disease to trial treatments, including, most recently, gene therapy. Gene therapy treatments have shown successful results in halting the advancement of Batten disease, and it is believed that this treatment may soon lead to clinical trials. The Neurological Foundation has funded this research for the past 21 years, and with your support, we can continue to help this incredible research move forward.

 

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