The following grants were approved prior to July 2016
Assessing RRMS patient sera for soluble blood brain barrier disrupting factors
Does a subset of multiple sclerosis patients have a dysfunction to the barrier protecting the brain?
Relapsing remitting multiple sclerosis (RRMS) is a chronic neurological condition where the immune system attacks structures in the brain. The disruption to the blood vessels in the brain in the regions where the lesions form is a key feature of multiple sclerosis pathology. Dr Graham’s research aims to investigate whether RRMS patients have soluble factors circulating in their blood that can directly cause disruption to the special vascular structure known as the blood brain barrier (BBB). The BBB protects the brain from foreign substances in the blood that may injure the brain. Identification of these factors will provide an understanding of mechanisms involved in blood brain barrier dysfunction and in the future lead to strategies that directly strengthen the compromised vessels.