Chloride co-transport – a driving force for treating human cerebellar ataxias

$193,844

Associate Professor Ruth Empson
Department of Physiology University of Otago

When did you last take for granted your ability to enjoy a cup of coffee without spilling it everywhere? Ataxia, or loss of controlled movement, occurs when the electrical signals in a part of your brain called the cerebellum go wrong. Ataxia can affect anyone, young or old, has a variety of causes, usually gets worse and is rarely reversible. In this laboratory-based project we focus on a novel therapeutic mechanism that aims to correct these wayward electrical signals as a promising way to restore cerebellar function and effortless movement control in ataxic humans.